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GRIT-LAB is committed to publishing impactful research across multiple disciplines
Publications offer just a glimpse into our world. At GRIT-lab, we’re eager to engage in collaborative exchanges through conference presentations, poster sessions, and on/off-line discussions.
- 2023
Jungjoon K. Lee, Soobon Ko, Kyungsoo Ha, Yoonjoo Choi, Assessing the Predictive Ability of Computational Epitope Prediction Methods on Fel d 1 Allergen, bioRxiv, 2023.06. 01.543222
Jungjoon K. Lee*, Removing the Barrier between Cellular-Based and Biochemical Methods. RRJ Biol. 2023;11:003
Young-hoon Kim, Nahye Kim, Ikenna Okafor, Sungchul Choi, Seonwoo Min, Joonsun Lee, Seung-Min Bae, Keunwoo Choi, Janice Choi, Vinayak Harihar, Youngho Kim, Jin-Soo Kim, Benjamin Kleinstiver, Jungjoon K. Lee*, Taekjip Ha*, Hyongbum Henry Kim*, Sniper2L is a high-fidelity Cas9 variant with high activity, Nature Chemical Biology, 2023
Jeonghun Kwon, Minyoung Kim, Woochang Hwang, Anna Jo, Gue-Ho Hwang, Minhee Jung, Un Gi Kim, Gang Cui, Heonseok Kim, Joon-Ho Eom, Junho K. Hur, Junwon Lee, Youngho Kim, Jin-soo Kim, Sangsu Bae, Jungjoon K. Lee*, Extru-seq: a method for predicting genome-wide Cas9 off-target sites with advantages of both cell-based and in vitro approaches, Genome Biology, 2023, 24, Article number: 4.
- 2022
Jeonghun Kwon, Minyoung Kim, Seungmin Bae, Anna Jo, Youngho Kim, Jungjoon K. Lee*, TAPE-seq is a cell-based method for predicting genome-wide off-target effects of prime editor, Nature Communications, 2022, 13, Article number: 7975.
- 2021
Jungjoon Lee*, Yoonjoo Choi*, Wet Lab Goes Virtual: In Silico Tools, ELNs, and Big Data Help Scientists Generate and Analyze Wet-lab Data, WILEY‐VCH GmbH, 2021
- 2020
Jungjoon K. Lee*, Directed evolution of CRISPR-Cas9 to increase specificity, 2020, Research OUTREACH (112). DOI: 10.32907/RO-112-158161
- 2019
Ikenna C Okafor, Digvijay Singh, Yanbo Wang, Minhee Jung, Haobo Wang, John Mallon, Scott Bailey, Jungjoon K. Lee, Taekjip Ha*, Single molecule analysis of effects of non-canonical guide RNAs and specificity-enhancing mutations on Cas9-induced DNA unwinding, Nucleic Acids Res. 2019 Dec 16; 47(22): 11880–11888.
Joonsun Lee, Minhee Jung, Euihwan Jeong, Jungjoon K. Lee*, Using Sniper-Cas9 to Minimize Off-target Effects of CRISPR-Cas9 Without the Loss of On-target Activity Via Directed Evolution. J. Vis. Exp. (144), 2019, e59202, doi:10.3791/59202.
- 2018 and before
Jungjoon K. Lee*, Euihwan Jeong, Joonsun Lee, Minhee Jung, Eunji Shin, Young-hoon Kim, Kangin Lee, Inyoung Jung, Daesik Kim, Seokjoong Kim & Jin-Soo Kim*, Directed evolution of CRISPR-Cas9 to increase its specificity, Nature Communications, 2018; 9, Article number: 3048.
Taeyoung Koo1, Jungjoon K. Lee1, Jin-soo Kim*, Measuring and Reducing Off-Target Activities of Programmable Nucleases Including CRISPR-Cas9. Mol Cells. 2015 Jun;38(6):475-81. doi: 10.14348/molcells.2015.0103. Epub 2015 May 19. PMID: 25985872; PMCID: PMC4469905.
Jungjoon Lee, Kyung Hyun Lee, Jongho Jeon, Anca Dragulescu-Andrasi, Fei Xiao, Jianghong Rao, Combining SELEX Screening and Rational Design to Develop Light-Up Fluorophore− RNA Aptamer Pairs for RNA Tagging, ACS Chem. Biol. 2010, 5, 11, 1065–1074
Marcello Forconi, Jihee Lee, Jungjoon K. Lee, Joseph A Piccirilli, Daniel Herschlag, Functional identification of ligands for a catalytic metal ion in group I introns, Biochemistry 2008, 47, 26, 6883–6894
Freija G. Glansdorp, Gemma L. Thomas, Jungjoon K. Lee, Jenny M. Dutton, George PC. Salmond, Martin Welch, David R. Spring, Synthesis and stability of small molecule probes for Pseudomonas aeruginosa quorum sensing modulation, Org. Biomol. Chem., 2004,2, 3329-3336
conferences
- Jungjoon K. Lee (2024, Mar 20-21). Innovations in off-target detection for Safer Clinical Trial [Oral presentation]. 2nd Annual Clinical Trials Festival Asia 2024, Singapore, Singapore.
- Jungjoon K. Lee (2023, Nov 28-30). Overcoming the Trade-Off Between Specificity and Activity [Oral Presentation]. 4th annual CRISPR 2.0 Conference, Boston, MA. USA.
- Jungjoon K. Lee (2023, Oct 12-13). Development of cutting-edge CRISPR and off-target prediction methods [Oral presentation]. BioCon Asia- Advanced Cell & Gene Therapy (ACGT) Conference, Singapore, Singapore.
- Jungjoon K. Lee (2023, July 19-20). TAPE-seq: A Cell-Based Method for Predicting Genome-Wide Off-Target Effects of Prime Editor [Oral presentation]. The 8th World Congress on Cancer Research & Therapy, Frankfurt, Germany.
- Jungjoon K. Lee (2023, May 16 - May 20). TAPE-seq is a Cell-Based Method for Predicting Genome-Wide Off-Target Effects of Prime Editor [Poster presentation]. ASGCT 26th Annual Meeting, Los Angeles, CA. USA.
- Jungjoon K. Lee (2018, June 24-29). Directed Evolution of CRISPR-Cas9 to Increase its Specificity [Poster presentation]. FASEB Genome Engineering Conference, Florence, Italy
- Jungjoon K. Lee (2017, Oct 22-24). Directed Evolution of CRISPR-Cas9 to Increase its Specificity [Poster presentation]. Cell Symposium: CRISPR: From Biology to Technology and Novel Therapeutics fast approaches, Sitges, Spain
- Jungjoon K. Lee (2023, Nov 28-30). Defining Thresholds and Cut-Off Values for Off-Target Analysis [Panel Discussion]. 4th annual CRISPR 2.0 Conference, Boston, MA. USA.
- Jungjoon K. Lee (2023, Oct 30- Nov 1). Standardizing Genome-Wide Off-Target Prediction Methods [Oral Presentation]. CRISPR-Based Therapy Analytical Development Summit, Boston, MA. USA.
- Jungjoon K. Lee (2023, Sep 14-15). Next Generation Gene Editing for Genetic Disease, [Oral presentation]. 7th Annual Cell and Gene Therapy World Asia, Singapore, Singapore
- Jungjoon K. Lee (2023, May 16 - May 20). Sniper2L, a High-Fidelity Cas9 Variant with High Activity [Oral presentation]. ASGCT 26th Annual Meeting, Los Angeles, CA. USA.
- Jungjoon K. Lee (2023, May 16 - May 20). Extru-seq: A Method for Predicting Genome-Wide Cas9 Off-Target Sites with Advantages of Both Cell-Based and In Vitro Approaches [Poster presentation]. ASGCT 26th Annual Meeting, Los Angeles, CA. USA.
- Jungjoon K. Lee (2018, Feb 7-8). Directed Evolution of CRISPR-Cas9 to Increase its Specificity [Poster presentation]. The 9th Takeda Science Foundation Symposium on Pharma Sciences, Osaka, Japan
- Jungjoon K. Lee (2017, Sep 27-29). Directed Evolution of CRISPR-Cas9 to Increase its Specificity [Oral presentation]. IBS-Nature Conference on Frontiers on Genome Engineering, Seoul, Korea
seeking partners
At GRIT-Lab, a valued member of the Synthetic Biology for Clinical and Technological Innovation (SynCTI) Program at the National University of Singapore (NUS), we are dedicated to harnessing the power of collaboration to advance the field of genome editing.
